Scientific Outputs​

Scientific Publications​

Detection of Neutralizing Antibodies in COVID-19 Patients from Steve Biko Academic Hospital Complex: A Pilot Study, 2023

Kgatle, M., Chalwe. J.M., van der Westhuizen, D., Xu, X., Damane, B.P., Mathebela, P., Ueckermann, V., Mayaphi, S., Gomes Rodrigues, H., Moura-Alves, P., Ndlovu, H., Mzizi, Y., Zongo, L., Hairwadzi, H., Vorster, M., Zeevart, J.R., Sathekge, M. Detection of Neutralizing Antibodies in COVID-19 Patients from Steve Biko Academic Hospital Complex: A Pilot Study. July, 2023.

DOI: 10.3390/covid3070072

Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition, 2023

H. Matthew Berns, Dawn E. Watkins-Chow, Sizhu LuPakavarin Louphrasitthiphol, Tongwu Zhang, Kevin M. BrownPedro Moura-Alves, Colin R. Goding, William J. Pavan, Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition , March, 2023.

DOI:  https://doi.org/10.1101/2023.03.10.532018

Targeting the Aryl Hydrocarbon Receptor by gut phenolic metabolites: A strategy towards gut inflammation, 2023

Pinto, C.J.G., Ávila-Gálvez, M.Á., Lian, Y., Moura-Alves, P.$, Nunes dos Santos, C.*,  Targeting the aryl hydrocarbon receptor by gut phenolic metabolites: A strategy towards gut inflammation., Redox Biology (2023), February 1, 2023.

DOI: 10.1016/j.redox.2023.102622

The highly potent AhR Agonist Picoberin Modulates Hh-Dependent Osteoblast differentiation, 2022

Flegel, J., Shaaban,S., Jia, Z.K., Schulte, B., Lian, Y., Krzyzanowski, A.,Metz, M., Schneidewing, T., Wesseler, F., Flegel, A., Reich, The highly potent AhR agonist Picoberin modulates Hh-dependent osteoblast differentiation., Journal of Medicinal Chemistry (2022), December 22.

DOI: 10.1021/acs.jmedchem.2c00956

Aryl Hydrocarbon Receptor Modulation by Tuberculosis Drugs Impairs Host Defense and Treatment Outcomes. Cell Host and Microbe27(2):238-248.e7, 2020

[Journal: Article] [CI: 16] [IF: 21]

Puyskens A., Stinn A., van der Vaart M., Kreuchwig A., Protze J., Pei G., Klemm M., Guhlich-Bornhof U., Hurwitz R., Krishnamoorthy G., Schaaf M., Krause G., Meijer A.H., Kaufmann S.H.E., Moura-Alves P.

DOI: 10.1016/j.chom.2019.12.005 SCOPUS: 85078995730.

Host monitoring of quorum sensing during Pseudomonas aeruginosa infection. Science366(6472):, 2019

[Journal: Article] [CI: 55] [IF: 41,8]

 

Moura-Alves P., Puyskens A., Stinn A., Klemm M., Guhlich-Bornhof U., Dorhoi A., Furkert J., Kreuchwig A., Protze J., Lozza L., Pei G., Saikali P., Perdomo C., Mollenkopf H.J., Hurwitz R., Kirschhoefer F., Brenner-Weiss G., Weiner J., Oschkinat H., Kolbe M., Krause G., Kaufmann S.H.E.,

 

DOI: 10.1126/science.aaw1629 SCOPUS: 85077079979.

The Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasis. Scientific Reports9(1):, 2019

[Journal: Article] [CI: 11] [IF: 4]

 

Lozza L., Moura-Alves P., Domaszewska T., Lage Crespo C., Streata I., Kreuchwig A., Puyskens A., Bechtle M., Klemm M., Zedler U., Silviu Ungureanu B., Guhlich-Bornhof U., Koehler A.B., Stäber M., Mollenkopf H.J., Hurwitz R., Furkert J., Krause G., Weiner J., Jacinto A., Mihai I., Leite-de-Moraes M., Siebenhaar F., Maurer M., Kaufmann S.H.E.

 

DOI: 10.1038/s41598-019-47350-x SCOPUS: 85069718136.

IL-36/LXR axis modulates cholesterol metabolism and immune defense to Mycobacterium tuberculosis. Scientific Reports8(1):, 2018

[Journal: Article] [CI: 22] [IF: 4]

 

Ahsan F., Maertzdorf J., Guhlich-Bornhof U., Kaufmann S.H.E., Moura-Alves P.

 

DOI: 10.1038/s41598-018-19476-x SCOPUS: 85041098857.

Role of Interleukin 36γ in Host Defense Against Tuberculosis. Journal of Infectious Diseases214(3):464-474, 2016

[Journal: Article] [CI: 26] [IF: 6,3]

 

Ahsan F., Moura-Alves P., Guhlich-Bornhof U., Klemm M., Kaufmann S.H.E., Maertzdorf J.

 

DOI: 10.1093/infdis/jiw152 SCOPUS: 84981225435.

AhR sensing of bacterial pigments regulates antibacterial defence. Nature512(7515):387-392, 2014

[Journal: Article] [CI: 228] [IF: 41,5]

 

Moura-Alves P., Faé K., Houthuys E., Dorhoi A., Kreuchwig A., Furkert J., Barison N., Diehl A., Munder A., Constant P., Skrahina T., Guhlich-Bornhof U., Klemm M., Koehler A.B., Bandermann S., Goosmann C., Mollenkopf H.J., Hurwitz R., Brinkmann V., Fillatreau S., Daffe M., Tümmler B., Kolbe M., Oschkinat H., Krause G., Kaufmann S.H.E.

 

DOI: 10.1038/nature13684 SCOPUS: 84907382483.

Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome. Cellular Microbiology12(8):1046-1063, 2010

[Journal: Article] [CI: 240] [IF: 5,6]

 

Mishra B.B., Moura-Alves P., Sonawane A., Hacohen N., Griffiths G., Moita L.F., Anes E.

 

DOI: 10.1111/j.1462-5822.2010.01450.x SCOPUS: 77957133396.

An shRNA-based screen of splicing regulators identifies SFRS3 as a negative regulator of IL-1ß secretion. PLoS ONE6(5):, 2011

[Journal: Article] [CI: 8] [IF: 4,1]

 

Moura-Alves P., Neves-Costa A., Raquel H., Pacheco T.R., D’Almeida B., Rodrigues R., Cadima-Couto I., Chora A., Oliveira M., Gama-Carvalho M., Hacohen N., Moita L.F.

 

DOI: 10.1371/journal.pone.0019829 SCOPUS: 79956068797.

Seminar Organization

22/04/2024 | Pritesh Jaychand Lalwani | Epidemiological and Immunological Surveillance of Infectious Diseases in Amazonia

22/04/2024 | Epidemiological and Immunological Surveillance of Infectious Diseases in Amazonia | Satellite Seminar

Pritesh Jaychand Lalwani
[Instituto Leônidas e Maria Deane (ILMD/Fiocruz Amazônia), Manaus, Brasil | Lead Participant]

22/03/2024 | Mohlopheni Jackson Marakalala | Inflammatory mediators of TB granuloma caseation

22/04/2024 | Inflammatory mediators of TB granuloma caseation | Friday Noon Seminars

Mohlopheni Jackson Marakalala
[Africa Health Research Institute | Lead Participant]

21/02/2024 | Zdenek Dvorak | Aryl Hydrocarbon Receptor targeting with allosteric and orthosteric ligands

22/04/2024 | Aryl Hydrocarbon Receptor targeting with allosteric and orthosteric ligands | Satellite Seminar

Zdenek Dvorak
[Department of Cell Biology and Genetics, Faculty of Science, Palacký University Olomouc, Czechoslovakia | Lead Participant]

03/10/2023 | Andreas Diefenbach | The innate immune system and tissue homeostasis

03/10/2023 | The innate immune system and tissue homeostasis6th i3S PhDay

Andreas Diefenbach
[Institute of Microbiology, Infectious Diseases and Immunology, Charité – Universitätsmedizin Berlin | Lead Participant]

17/03/2023 | Alan Sher | Microbial priming of the lung for control of SARS-CoV2 infection

17/03/2023 | Microbial priming of the lung for control of SARS-CoV2 infection

Alan Sher
[National Institute of Allergy and Infectious Disease (NIH), USA| Lead Participant]

 

28/10/2022 | Stefan H.E. | Tuberculosis: From basic research to rational design of novel diagnostic and preventive measures

28/10/2022 | Tuberculosis: From basic research to rational design of novel diagnostic and preventive measures

Stefan H.E.
[Max Plank Institute, Germany | Lead Participant]

Scientific Event Organization

18/10/2023 | PhasAGE R&I Winter School, i3S
24/05/2023 | i3S - Infection, Immunity and Regeneration Programme Retreat

Ordem dos Médicos, Porto, Portugal

Pedro Moura-Alves, Helena Azevedo, Inês Gonçalves

Organization Committee ]

17/03/2023 | I ImmunoHUB Annual Meeting, i3S
09/02/2023 | 9th MCBiology Advanced Course in Infection and Immunity

i3S, Porto, Portugal

Pedro Moura-Alves, Margarida Saraiva, Nuno Alves

Organization Committee ]

04/03/2022 | 8th MCBiology Advanced Course in Infection and Immunity

i3S, Porto, Portugal

Pedro Moura-Alves, Margarida Saraiva, Nuno Alves

Organization Committee ]

Scientific Event Participation

17/10/2023 | iMed Conference 15.0

Nova Medical School, Lisboa, Portugal.

+ Info: https://imedconference.org/

Talk: The AHR: from a xenobiotic sensor to a Pattern Recognition Receptor, playing a role in immunity to infection and drug-therapy

Inês Almeida

[ Participant ]

27/06/2023 | X BiotechHealth Annual Meeting Symposium

i3S, Porto, Portugal

+ Info: https://biotechhealth2023.wixsite.com/x-symposium

Tânia Lima

[ Invited speaker, Round Table Discussion ]

23/05/2023 | XXVIII Infection and Sepsis Symposium

Porto, Portugal

+ Info: https://eventos.gis.pt/Ficheiros/28ISS/SEPSIS_%20Program_2023.pdf

Talk: Sensing bacterial quorum: an AHR guided tour to host defence mechanisms and drug efficacy during infection

Pedro Moura-Alves

10/05/2023 | IJUP - Investigação Jovem Universidade do Porto

University of Porto, Porto, Portugal

+info: https://www.up.pt/ijup/ijup-2023/

Talk: Dissecting the roles of the Aryl Hydrocarbon Receptor in melanoma: from a sensor to a regulator of the melanoma microenvironment

Beatriz Moreira

10/05/2023 | IJUP - Investigação Jovem Universidade do Porto

University of Porto, Porto, Portugal

+ Info: https://www.up.pt/ijup/ijup-2023/

Talk: T(AHR)getting the AHR: mapping the road of a xenobiotic sensor, from disease to a therapeutic target

Inês Almeida

27/04/2023 | II TOXRUN International Congress

Hotel Cristal, Porto, Portugal

+ Info: https://toxrun.iucs.cespu.pt/congress2023/

Talk: The AHR: from a xenobiotic sensor to a Pattern Recognition Receptor, playing a role in immunity to infection and drug-therapy

Pedro Moura-Alves

27/04/2023 | II TOXRUN International Congress

Hotel Cristal, Porto, Portugal

+ Info: https://toxrun.iucs.cespu.pt/congress2023/

Poster: T(AHR)getting the AHR: mapping the road of a xenobiotic sensor, from disease to a therapeutic target

Inês Almeida

12/04/2023 | XIV Biochemistry Day

University of, Aveiro, Portugal

Poster: T(AHR)getting the AHR: mapping the road of a xenobiotic sensor, from disease to a therapeutic target

Inês Almeida

29/03/2023 | XLVIII Sociedade Portuguesa Imunologia Annual Meeting
22/03/2023 | 26th symposium: Infection and Immune Defense

German Society for Immunology (DGfI) Rothenfels, Germany

+ Info: https://dgfi.org/arbeitskreise/ak-infektionsimmunologie/meeting/

Talk: AHR sensing bacterial quorum during infection

Pedro Moura-Alves

13/02/2023 | 7th Symposium of the MSc in Oncology

Instituto Português Oncologia, Porto, Portugal

Talk: Dissecting the roles of the Aryl Hydrocarbon Receptor in melanoma: from a sensor to a regulator of the melanoma microenvironment

Beatriz Moreira

09/02/2023 | 9th McBiology Symposium
15/07/2022 | IRCI2022 - Immune Responses in Cancer and Infection

Centre International de Recherche en Infectiologie, Lyon, France

+ Info: https://www.ludwig.ox.ac.uk/news/ludwig-oxford-retreat-2022-2013-a-recap

Pedro Moura-Alves

20/06/2022 | AHR symposium 2022 - Toxicity to Therapeutics

Penn State University, Pennsylvania, USA

+ Info: https://www.cmtc.psu.edu/2022/07/07/dr-gary-perdew-and-penn-state-university-to-host-2022-ahr-symposium/

Talk: AHR sensing bacterial quorum during infection

Pedro Moura-Alves

14/06/2022 | IRCI2022 - Immune Responses in Cancer and Infection

Centre International de Recherche em Infectiologie, Lyon, France.

+ Info:

IRCI 2022: Immune Responses in Cancer and Infection

Pedro Moura-Alves

14/06/2022 | LICR Retreat

Ludwig Institute for Cancer Research, Oxford, UK

+ Info: https://www.ludwig.ox.ac.uk/news/ludwig-oxford-retreat-2022-2013-a-recap

Talk: Connections in the AHR: a ticket to multiple destinations in infection, cancer and therapy

Pedro Moura-Alves

12/05/2022 | Porto Cancer Meeting
01/04/2022 | Workshop: Manuscript Writing and Publication

Fundação Calouste Gulbenkian, Lisbon, Portugal

Pedro Moura-Alves

04/04/2022 | Workshop: Pathogen Immunity and Signaling

EMBO, Saint-Malo, France

+ Info: https://meetings.embo.org/event/21-signaling

Talk: AhR sensing bacterial quorum during infection and its impact on antibiotic therapy

Pedro Moura-Alves

Seminars

16/11/2022 | Instituto Gulbenkian Ciência

Lisboa, Portugal

Pedro Moura-Alves

 

04/05/2023 | i3S - Instituto de Investigação e Inovação em Saúde

Porto, Portugal

Pedro Moura-Alves

Talk: Connections in the AHR: a ticket to multiple destinations in infection, immunity and therapy

29/11/2022 | CICS - Health Sciences Research Center, University Beira Interior 

Covilhã, Portugal

Pedro Moura-Alves

24/11/2022 | Lund Stem Cell Center, Lund University

Lund, Sweden

Pedro Moura Alves

22/11/2022 | Skin Immunology Research Center, Department of Immunology and Microbiology

Copenhagen, Denmark

Pedro Moura-Alves

 

11/07/2022 | ICVS - Life and Health Sciences Research Institute University of Minho

Braga, Portugal

Pedro Moura-Alves

 

06/07/2022 | Department of Infection Immunity and Cardiovascular Disease, University of Sheffield

Sheffield, UK

Pedro Moura-Alves

 

24/06/2022 | Albany Medical Center
Albany , USA Pedro Moura-Alves
01/06/2022 | The Duve Institute-Université Catholique de Louvain

Louvain, Belgium

Pedro Moura-Alves

 

 

04/05/2022 | Microbiology Institute-Friedrich Alexander University Erlangen

Erlangen, Germany

Pedro Moura-Alves

 

Jury / Evaluation Panel

3-4/10/2023 | i3S, Portugal

Event: 6th i3S PhD Symposium

Palmira Barreira-Silva

[ Abstract Evaluator ]

29/09/2023 | University of Coimbra, Chemistry Engineering Department

Event: Chemical Engineering MSc thesis defence

Pedro Curto

[ Main Opponent ]

17/03/2023 | i3S, Portugal

Event: I ImmunoHUB Annual Meeting

Pedro Moura-Alves, Pedro Curto, Tãnia Lima,Palmira Barreira- Silva

Abstract Evaluator ]

17/03/2023 | i3S, Portugal

Event: I ImmunoHUB Annual Meeting

Beatriz Moreira, Inês Almeida

[ Oral Presentation Evaluation ]

23-24/02/2023 | i3S, Portugal

Event: 9th MCbiology Symposium

Palmira Barreira-Silva

Poster Evaluator ]